My main use case for a desktop machine is cad. I come from an analog graphics background (I’m old). The whole arrangement of tech for graphics is inhuman and apparently designed to torture artists ;) Humans evolved over millions of years to have a finely tuned hand to eye coordination- that is your hands are directly within your field of view while you are using them. The brain requires this and forcing the hands out of view to operate a mouse limits the brain’s ability to function. Humans evolved as bipeds to stand, walk and move from a vertical position. Sitting unmoving in a chair for a significant portion of the day is damaging to the skeletomuscular and nervous systems. Compressing the human scale of motion onto a screen of less than or just barely within (in the very best case) the size of the human field of view limits the amount of motion the head, neck and spine get during the day. Over time this leads to more damage.