Virtualization, as a commercial product pointed at businesses, is a legacy product.
Of course large providers are utilizing virtualization, containerization and an abundance of similar technologies. However, they’re not generally using VMware to do it.
I spoke in the context of OPs question.
Once the alleged infringing content is removed, the infringing party has the option to file a Counter Claim in response, stating under penalty of perjury that the DMCA Notice is false. The OSP/ISP must wait 10-14 days after receiving a valid DMCA Counter Claim before reactivating or allowing access to the claimed infringing content. The claimant who filed the DMCA Takedown Notice must then file a court order against the infringing site owner and the OSP/ISP if they wish to keep the infringing content offline.
Self-hosters are also subject to DMCA. Failure to comply runs the risk of being sued.