• 1 Post
  • 94 Comments
Joined 1 year ago
cake
Cake day: June 8th, 2023

help-circle


  • There are a lot of missing steps people don’t really understand yet R.E. how this all amounts to something complicated like “a liver”. But we think that the basic building block of it is that there are gradients of chemical concentration that some cells set up, and then other cells react to the level of the chemical and decide to different things. There’s a famous analogy of the French Flag Model, where the different stripes of the French flag are imagined to emerge from how far you are from the left edge where a “morphogen” chemical is coming from, because cells detect and react to different concentrations of the chemical in different ways.

    And the cells do these things because the DNA programs them to do it. Some genes produce proteins that can turn around and bind to the DNA that encodes other genes, and make those other genes produce more or fewer proteins of their own. Proteins can be made so that they bind or unbind DNA in the presence of other proteins, or particular chemicals, or which can function to turn one chemical into another. So you can have little logic circuits made out of genes that measure chemicals and turn other genes on and off. And you can have little memory circuits based on which genes have things bound to them and which ones are currently on or off, so the cells can remember what it is they decided to be. And so the cells are programmed to differentiate into progressively more specific cell types over time depending on what signals they see, with the morphogen gradients or combinations of them allowing the cells to have some idea of where they are in the body.

    And the proteins are these little squishy clicky things, like long strings of magnets that will snap into certain shapes, or that can swap between a few shapes. They can be shaped so they fit really nicely against certain shapes of DNA sequence or other proteins, or so that they fit really nicely against small molecules with a piece pushing on the molecule in just the right place to make it easy for an atom to break off the end of it or whatever. And because they live in this weird tiny world where everything is constantly vibrating around and banging against everything else (because of how tiny the volumes get when you shrink the lengths to cell size), this is enough for them to find and stick to the stuff they are shaped to stick to.

    Then depending on genetic variation between people, the proteins involved can e.g. have different set points for the concentrations they react to, and that can translate into the threshold between cells deciding to do one thing or another moving around in the body, and in turn translate into people having e.g. a wider or narrower region of their face decide to be a nose.



  • Like, each user is individually kicked off the PDS in reaction to some bad thing they did? Or labeling is reactive in that it labels bad stuff already posted, and each user has to pick labelers to listen to themselves?

    I’m not sure if Bluesky’s front-end defaults to using some particular labelers. I know there’s some moderation going on for you as soon as you log in, done by someone.

    But yes, each user has to choose whose moderation decisions they want to use, and they can’t rely on everyone they can see also seeing exactly the same space they themselves are seeing. But I’m not sure it’s possible or even desirable to get rid of the requirement/ability to choose your mods. I should be able to be in a community that has mods I trust, and the community chatting to itself and determining that so-and-so is a great mod who we should all listen to, and then all listening to them, sounds like a good idea to me.

    Being able to see and talk to people who aren’t in the same space I’m in might not be as good?



  • No?

    An anthropomorphic model of the software, wherein you can articulate things like “the software is making up packages”, or “the software mistakenly thinks these packages ought to exist”, is the right level of abstraction for usefully reasoning about software like this. Using that model, you can make predictions about what will happen when you run the software, and you can take actions that will lead to the outcomes you want occurring more often when you run the software.

    If you try to explain what is going on without these concepts, you’re left saying something like “the wrong token is being sampled because the probability of the right one is too low because of several thousand neural network weights being slightly off of where they would have to be to make the right one come out consistently”. Which is true, but not useful.

    The anthropomorphic approach suggests stuff like “yell at the software in all caps to only use python packages that really exist”, and that sort of approach has been found to be effective in practice.







  • Plastic at the microscopic level, if they aren’t doing anything chemically interesting, really ought to function about like “rock, but light”. Most organisms don’t run into trouble because there are tiny bits of rock in the world, so I would expect tiny bits of plastic not to be a huge problem. Which is sort of backed up by how we have noticed microplastics everywhere and we haven’t seen huge problems resulting from it (most people are still alive, most children still develop to adulthood, etc.).

    But it’s entirely possible that some of these plastics are not chemically inert, and that they emit chemicals that do exciting and unwanted things in people’s bodies. If we can’t keep our plastics from becoming microplastics, we probably need to discontinue the manufacture of non-implantable plastics, since all the plastics will end up in someone’s body at some point.

    And it’s also possible that the microplastics physically do do something interestingly bad. I think there was a recent study to this effect on heart disease. But at this point, that’s the question we need to be asking. How many or what kind of microplastics does it take to give a ferret epilepsy? Not “are there microplastics in my all brands of peanut butter?”





  • But now, or soon, you can have one person with half an idea, like “what if The Rock had to save Shanghai from mole zombies”, and they can grab a text generator to fill in most of the screenplay, and then dial in the number of synonyms for “exciting” used to describe the explosions, and come out with Day of the Living Moles, a 95 minute feature film, in a weekend. Without actually having to have had any traditional cinematography skills or breaking an artistic sweat.

    There are categories of creative work that are throw-away; little sketches on napkins, improvised songs, quick sketches that an artist might think of are of no account to anyone. And the scope of what can be dashed off like that, with minimal time and effort, is growing because of more powerful tools.

    Why should I watch Universal’s superhero blockbuster when I can watch my buddy Jimothy’s? What happens when the number of plausible films dramatically exceeds the time that movie critics have to watch them to sort out which are any good?




  • Does the server operator avoid any responsibility for data protection by just having the actual physical copies of all the data they do have access to (user names, post contents, etc.) physically live over at Discord? If the company president’s PC is hacked and someone steals copies of all the personal information in support chats that were conducted over Discord, or the contents of private channels where people posted their home addresses for Secret Santa, or whatever, can the company get out of having any sort of data breach disclosure obligations because the data was really Discord’s data?